Process for bicyclic .beta.-lactams diazo-.beta.-keto-butyrate-intermediates for bicyclic .beta.-lactams

Patent

Description

1-Carbapenam-2-one-3-carboxylic acid and 1-carba-3-hydroxy-3-cephem-4-carboxylic acid and esters thereof are provided by a process comprising a rhodium C.sub.2 -C.sub.10 carboxylate catalyzed cyclization of an ester of a 4-(1-alkoxy- or 1-substituted alkoxy)-2-oxo-4-azetidinyl)-.beta.-ketobutyric acid and an ester of a 5-(1-alkoxy- or 1-substituted alkoxy-2-oxo-4-azetidinyl)-.alpha.-diazo-.beta.-ketovaleric acid respectively. The process is carried out in an inert organic solvent at a temperature between about 15.degree. C. and about 85.degree. C. The 1-carba bicyclic .beta.-lactams are intermediates for preparing antibiotics.

Attributes

Attribute NameValues
Title
  • Process for bicyclic .beta.-lactams diazo-.beta.-keto-butyrate-intermediates for bicyclic .beta.-lactams

Patent Number
  • US 5106968 B2

USPTO Link
Inventor
  • Marvin J. Miller

  • Matthew A. Williams

Inventor From Local Institution
  • Marvin J. Miller

Other Application
  • 07/733,895

Claims
  • 7

Classification (US Patent)
  • 540/355;

Cooperative Patent Classification codes
  • C07D 477/04 (20130101); C07D 463/00 (20130101)

International Patent Classification codes
  • C07D 463/00 (20060101); C07D 477/00 (20060101); C07D 477/04 (20060101); C07D 205/08 (); C07D 205/085 (); C07D 487/04 ()

Language
  • eng

Date Issued
  • 1992-04-21

Publisher
  • United States Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

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