Azetidinone N-phosphonomethyl esters

Patent

Description

The invention provides azetidinones of the formula ##STR1## where R.sub.4 is hydrogen, amino or protected amino; R.sup.0 is H when R.sub.4 is amino or protected amino, or C.sub.1 -C.sub.4 alkyl when R.sub.4 is H; R.sub.1 is H, CH.sub.3, –CH.sub.2 –.sub.n Y where Y is OH, protected OH, –CH.sub.2 OH, protected –CH.sub.2 OH, halogen, COOH or protected COOH; n is 1 or 2; –CH.sub.2 –C(O)SR.sub.1 ‘ where R.sub.1 ’ is e.g., C.sub.1 -C.sub.4 alkyl; R.sub.2 is H or protecting group and R.sub.3 is e.g., alkyl or phenyl. The azetidinones obtained are useful intermediates to carbapenems and carbacephems and monocyclic antibacterials, e.g., .alpha.-(dialkylphosphono)-[[3.beta.-[2-(2-aminothiazol-4-yl)-2-(syn)metho xyiminoacetylamino]azetidin-2-one-1-yl]]acetic acid and pharmaceutically acceptable salts thereof.

Attributes

Attribute NameValues
Title
  • Azetidinone N-phosphonomethyl esters

Patent Number
  • US 4820815 B2

USPTO Link
Inventor
  • Marvin J. Miller

Inventor From Local Institution
  • Marvin J. Miller

Other Application
  • 07/091,804

Claims
  • 17

Classification (US Patent)
  • 540/200; 540/205; 540/363; 540/364; 548/112; 548/406; 548/413; 560/169; 560/170; 562/564; 562/567; 987/368;

Cooperative Patent Classification codes
  • C07F 9/65583 (20130101); C07F 9/5683 (20130101)

International Patent Classification codes
  • C07F 9/00 (20060101); C07F 9/568 (20060101); C07F 9/6558 (20060101); C07F 009/65 ()

Language
  • eng

Date Issued
  • 1989-04-11

Publisher
  • United States Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

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Content License
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