9,550,012 OCR.pdf (1.61 MB)

Tissue scaffolds having bone growth factors

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posted on 2017-08-01, 00:00 authored by Matthew J. Meagher, Robert J. Kane, Ryan K. Roeder

The invention provides a novel composite bone graft system utilizing a porous collagen scaffold having a matrix impregnated with calcium phosphate particles and more than one bioactive agent, one of which is conjugated to the matrix. The graft system exhibits increased mechanical strength and osteogenic properties by providing sites for tissue attachment and propagation. The bioactive agents are delivered to the scaffold via different mechanisms to enable sequential and sustained release of the bioactive agents over time.

History

Patent Number

US 9550012 B2

Other Application

14/452,422

USPTO Link

http://patft1.uspto.gov/netacgi/nph-Parser?patentnumber=9550012

Inventor

Ryan K. Roeder Matthew J. Meagher Robert J. Kane

Inventor from Local Institution

Ryan K. Roeder Matthew J. Meagher Robert J. Kane

Assignee

University of Notre Dame du Lac

Date Modified

2017-08-01

Language

English

Claims

18

Prior Publication Number

US 20150132354 A1

Publisher

U.S. Patent and Trademark Office

Cooperative Patent Classification Codes

A61L 27/46 (20130101); C08L 89/06 (20130101); A61L 27/54 (20130101); A61L 27/56 (20130101); A61L 27/46 (20130101); A61K 38/18 (20130101); A61K 38/1875 (20130101); A61K 38/1866 (20130101); A61L 2300/414 (20130101); A61L 2430/02 (20130101)

Contributor

Ryan K. Roeder|Matthew J. Meagher|Robert J. Kane

International Patent Classification Codes

A61K 38/18 (20060101); A61L 27/12 (20060101); A61L 27/24 (20060101); A61L 27/56 (20060101); A61L 27/54 (20060101); A61L 27/40 (20060101); A61L 27/46 (20060101); A61P 19/08 (20060101)

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