Stratification of left-side and right-side colon cancer



Compositions/methods for employing fresh-frozen or FFPE colon cancer tissue in left side colon cancer (LCC) and right-side colon cancer (RCC) disease patients for risk of relapse assessment/stratification is provided (3 strata and a 4 strata methodology). An RCC gene panel of 4 genes (FAM69A, CDX2, FAM84A, ITGA3), and 9 genes (FAM69A, CDX2, ITGA3, FAM84A, ITPRIP, RAB3B, SMAD3, PCSK5, MMP28), is provided. An LCC gene panel of 4 genes (NOX4, WNT5A, MMP3, IBSP), and a 9 genes (MMP3, WINT5A, NOX4, IBSP, SLC16A6, CYPIBI, TFAP2C, MATN3, ANKRD6), is provided. A microchip-based clinical tool, and a kit including a microchip, is presented. The invention also describes a computer-implemented method for assessing relative risk of relapse in LCC and/or RCC disease. An individual patient scoring method that presents a continuous stratification score useful in the post-surgical colon cancer management of LCC and/or RCC patient is also presented.


Attribute NameValues
  • Stratification of left-side and right-side colon cancer

Patent Number
  • US 9580756 B2

  • Steven Buechler

  • Amanda B. Hummon

Inventor From Local Institution
  • Steven Buechler

  • Amanda B. Hummon

Other Application
  • 14/209,266

Prior Publication Date
  • 2015-03-12

Prior Publication Number
  • US 20150072878 A1

  • 7

Cooperative Patent Classification codes
  • C12Q 1/6886 (20130101); G06F 19/70 (20130101); C12Q 2600/106 (20130101); C12Q 2600/158 (20130101); C12Q 2600/112 (20130101); G06F 19/3431 (20130101)

International Patent Classification codes
  • C12Q 1/68 (20060101); G06F 19/00 (20110101)

  • English

Date Issued
  • 2017-02-28

  • U.S. Patent and Trademark Office

  • University of Notre Dame du Lac

Record Visibility Public
Content License
  • All rights reserved

Departments and Units
Member of


Collections Featuring this Patent
Notre Dame Patents


Please Note: You may encounter a delay before a download begins. Large or infrequently accessed files can take several minutes to retrieve from our archival storage system.