9,580,756 OCR.pdf (3.45 MB)
Stratification of left-side and right-side colon cancer
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posted on 2017-08-01, 00:00 authored by Amanda B. Hummon, Steven BuechlerCompositions/methods for employing fresh-frozen or FFPE colon cancer tissue in left side colon cancer (LCC) and right-side colon cancer (RCC) disease patients for risk of relapse assessment/stratification is provided (3 strata and a 4 strata methodology). An RCC gene panel of 4 genes (FAM69A, CDX2, FAM84A, ITGA3), and 9 genes (FAM69A, CDX2, ITGA3, FAM84A, ITPRIP, RAB3B, SMAD3, PCSK5, MMP28), is provided. An LCC gene panel of 4 genes (NOX4, WNT5A, MMP3, IBSP), and a 9 genes (MMP3, WINT5A, NOX4, IBSP, SLC16A6, CYPIBI, TFAP2C, MATN3, ANKRD6), is provided. A microchip-based clinical tool, and a kit including a microchip, is presented. The invention also describes a computer-implemented method for assessing relative risk of relapse in LCC and/or RCC disease. An individual patient scoring method that presents a continuous stratification score useful in the post-surgical colon cancer management of LCC and/or RCC patient is also presented.
History
Patent Number
US 9580756 B2Other Application
14/209,266Inventor
Steven Buechler Amanda B. HummonInventor from Local Institution
Steven Buechler Amanda B. HummonAssignee
University of Notre Dame du LacDate Modified
2017-08-01Language
- English
Claims
7Prior Publication Number
US 20150072878 A1Publisher
U.S. Patent and Trademark OfficeCooperative Patent Classification Codes
C12Q 1/6886 (20130101); G06F 19/70 (20130101); C12Q 2600/106 (20130101); C12Q 2600/158 (20130101); C12Q 2600/112 (20130101); G06F 19/3431 (20130101)Contributor
Steven Buechler|Amanda B. HummonInternational Patent Classification Codes
C12Q 1/68 (20060101); G06F 19/00 (20110101)Additional Groups
- Applied and Computational Mathematics and Statistics
- Chemistry and Biochemistry
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