Systems and methods for detecting and quantifying a sequence of nucleotides

Patent

Description

Methods and systems of quantifying a target material in solution include detection of a size change of a hybridized nanoparticle. In particular, the examples include functionalizing a plurality of nanoparticles to adapt the nanoparticles to hybridize with a species-specific target material, measuring the size of the functionalized nanoparticles to predetermine a standard distribution of non-hybridized nanoparticles, introducing the functionalized nanoparticles in a solution containing species-specific target materials and/or non-target materials, and hybridizing the functionalized nanoparticles with the species-specific target material if present in the solution. The size of the nanoparticles in solution are then measured after hybridization, and the presence or non-presence of the species-specific target material is detected and/or quantified by comparing the measured size of the nanoparticles after hybridization to the standard distribution of non-hybridized nanoparticles.

Attributes

Attribute NameValues
Title
  • Systems and methods for detecting and quantifying a sequence of nucleotides

Patent Number
  • US 9657336 B2

USPTO Link
Inventor
  • Steven Ruggiero

  • Carol Tanner

Inventor From Local Institution
  • Steven Ruggiero

  • Carol Tanner

Other Application
  • 14/113,416

Prior Publication Date
  • 2014-02-13

Prior Publication Number
  • US 20140045722 A1

Claims
  • 11

Cooperative Patent Classification codes
  • C12Q 1/6825 (20130101); C12Q 1/6827 (20130101); C12Q 1/6834 (20130101); C12Q 1/6888 (20130101); C12Q 1/6825 (20130101); C12Q 1/6834 (20130101); C12Q 1/6825 (20130101); C12Q 1/6834 (20130101); C12Q 1/6827 (20130101); C12Q 1/6827 (20130101); C12Q 2563/155 (20130101); C12Q 2565/519 (20130101); C12Q 2563/155 (20130101); C12Q 2565/519 (20130101); C12Q 2565/607 (20130101); C12Q 2563/155 (20130101); C12Q 2565/537 (20130101); C12Q 2563/155 (20130101); C12Q 2565/537 (20130101); C12Q 2565/607 (20130101); C12Q 2563/155 (20130101); C12Q 2565/537 (20130101); C12Q 2565/607 (20130101); C12Q 2563/155 (20130101); C12Q 2565/519 (20130101); C12Q 2565/607 (20130101)

International Patent Classification codes
  • C12Q 1/68 (20060101)

Language
  • English

Date Issued
  • 2017-05-23

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame du Lac

Record Visibility and Access Public
Content License
  • All rights reserved

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