9,657,336 OCR.pdf (635.58 kB)
Systems and methods for detecting and quantifying a sequence of nucleotides
standard
posted on 2017-08-01, 00:00 authored by Carol Tanner, Steven RuggieroMethods and systems of quantifying a target material in solution include detection of a size change of a hybridized nanoparticle. In particular, the examples include functionalizing a plurality of nanoparticles to adapt the nanoparticles to hybridize with a species-specific target material, measuring the size of the functionalized nanoparticles to predetermine a standard distribution of non-hybridized nanoparticles, introducing the functionalized nanoparticles in a solution containing species-specific target materials and/or non-target materials, and hybridizing the functionalized nanoparticles with the species-specific target material if present in the solution. The size of the nanoparticles in solution are then measured after hybridization, and the presence or non-presence of the species-specific target material is detected and/or quantified by comparing the measured size of the nanoparticles after hybridization to the standard distribution of non-hybridized nanoparticles.
History
Patent Number
US 9657336 B2Other Application
14/113,416Inventor
Steven Ruggiero Carol TannerInventor from Local Institution
Steven Ruggiero Carol TannerAssignee
University of Notre Dame du LacDate Modified
2017-08-01Language
- English
Claims
11Prior Publication Number
US 20140045722 A1Publisher
U.S. Patent and Trademark OfficeCooperative Patent Classification Codes
C12Q 1/6825 (20130101); C12Q 1/6827 (20130101); C12Q 1/6834 (20130101); C12Q 1/6888 (20130101); C12Q 1/6825 (20130101); C12Q 1/6834 (20130101); C12Q 1/6825 (20130101); C12Q 1/6834 (20130101); C12Q 1/6827 (20130101); C12Q 1/6827 (20130101); C12Q 2563/155 (20130101); C12Q 2565/519 (20130101); C12Q 2563/155 (20130101); C12Q 2565/519 (20130101); C12Q 2565/607 (20130101); C12Q 2563/155 (20130101); C12Q 2565/537 (20130101); C12Q 2563/155 (20130101); C12Q 2565/537 (20130101); C12Q 2565/607 (20130101); C12Q 2563/155 (20130101); C12Q 2565/537 (20130101); C12Q 2565/607 (20130101); C12Q 2563/155 (20130101); C12Q 2565/519 (20130101); C12Q 2565/607 (20130101)Contributor
Steven Ruggiero|Carol TannerInternational Patent Classification Codes
C12Q 1/68 (20060101)Usage metrics
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