Supramolecular Loading of a Broad Spectrum of Molecular Guests in Hyperbranched Polytriazole Nanoparticles with Cores Containing Multiple Functional Groups

Article

Abstract

hydrophobic (i.e., Hoechst 33342) dyes or drugs, including a binary dye/drug pair (i.e., indocyanine green/mitoxantrone). The core of HBPn, containing a mixture of uncharged 2-pentanone chains and 1,2,3-triazole rings, could be loaded with uncharged and very hydrophobic dyes (i.e., Nile Red) or drugs. Improved aqueous solubility of camptothecin was achieved 10-fold from 8.4 to 75 ng/mL. Additionally, cell toxicity studies showed that HBPn was able to release the camptothecin drug inside A549 cancer cells resulting in increased cell death. Taken together, the results suggest that this new family of water-soluble hyperbranched polytriazoles could be broadly useful as nanocarriers for various applications in therapy, imaging, or a combination of the two (theranostics).

Attributes

Attribute NameValues
Creator
  • Sasha Padilla-Coley

  • Hui Xu

Journal or Work Title
  • Bio Macromolecules

Volume
  • 21

Issue
  • 6

First Page
  • 2165

Last Page
  • 2175

Number of Pages
  • 10

ISSN
  • 15264602

Publication Date
  • 2020-04

Subject
  • Deltavision Deconvolution Microcope

Publisher
  • American Chemical Society

Date Created
  • 2020-06-26

Language
  • English

Departments and Units
Record Visibility Public
Content License
  • All rights reserved

Digital Object Identifier

doi:10.1021/acs.biomac.0c00151

This DOI is the best way to cite this article.