10087489OCR.pdf (2.34 MB)
Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease
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posted on 2019-02-18, 00:00 authored by Amanda B. Hummon, Steven BuechlerGenetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression values of the biomarkers are also presented. Computer implemented methods employing the biomarkers, and as well as for determining relapse-free survival probability in a patient having RCC or LCC are provided. A genetic method for classifying a colon cancer tissue as a RCC or as a LCC is also disclosed.
History
Patent Number
US 10,087,489 B2Other Application
15/276,131Inventor
Steven Buechler Amanda B. HummonInventor from Local Institution
Steven Buechler Amanda B. HummonAssignee
University of Notre Dame Du LacDate Modified
2019-02-18Language
- English
Claims
10Prior Publication Number
US 20170283877 A1Publisher
U.S. Patent and Trademark OfficeCooperative Patent Classification Codes
G01N 33/57419 (20130101); C12Q 1/6886 (20130101); C12Q 1/686 (20130101); C12N 5/0693 (20130101); G01N 33/57484 (20130101); G01N 2800/54 (20130101); C12Q 2600/106 (20130101); C12Q 2600/118 (20130101); C12Q 2600/158 (20130101)Contributor
Steven Buechler|Amanda B. HummonInternational Patent Classification Codes
C12Q 1/68 (20180101); G01N 33/574 (20060101); C12Q 1/6886 (20180101); C12N 5/09 (20100101); C12Q 1/686 (20180101)Additional Groups
- Chemistry and Biochemistry
- Applied and Computational Mathematics and Statistics
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