Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease

Patent

Description

Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression values of the biomarkers are also presented. Computer implemented methods employing the biomarkers, and as well as for determining relapse-free survival probability in a patient having RCC or LCC are provided. A genetic method for classifying a colon cancer tissue as a RCC or as a LCC is also disclosed.

Attributes

Attribute NameValues
Title
  • Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease

Patent Number
  • US 10,087,489 B2

USPTO Link
Inventor
  • Steven Buechler

  • Amanda B. Hummon

Inventor From Local Institution
  • Steven Buechler

  • Amanda B. Hummon

Other Application
  • 15/276,131

Prior Publication Date
  • 2017-10-05

Prior Publication Number
  • US 20170283877 A1

Claims
  • 10

Cooperative Patent Classification codes
  • G01N 33/57419 (20130101); C12Q 1/6886 (20130101); C12Q 1/686 (20130101); C12N 5/0693 (20130101); G01N 33/57484 (20130101); G01N 2800/54 (20130101); C12Q 2600/106 (20130101); C12Q 2600/118 (20130101); C12Q 2600/158 (20130101)

International Patent Classification codes
  • C12Q 1/68 (20180101); G01N 33/574 (20060101); C12Q 1/6886 (20180101); C12N 5/09 (20100101); C12Q 1/686 (20180101)

Language
  • English

Date Issued
  • 2018-10-02

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

Record Visibility and Access Public
Content License
  • All rights reserved

Departments and Units
Member of

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Collections Featuring this Patent
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