Accelerated Progression Relapse Test

Patent

Description

An Accelerated Progression Relapse Test (APRT) is provided for use in the prognosis of a diseased state in a patient. The APRT provides a determination of when a patient in a particular diseased state is likely to benefit from further disease treatment, or does not have a high probability of benefit with additional treatment. In particular applications, the APRT may be used to determine the prognosis of an estrogen receptor positive (ER+) breast cancer patient. Four genetic probes are disclosed for this test, and target MK167, CDC6 and SPAG5 gene products. The ER+ breast cancer patient/patient population is stratified into two groups, with the low gene expression group identifying the patient/patient group that is less likely to benefit from additional treatment measures, and a high gene expression group identifying the patient/patient group as more likely to benefit from additional treatment measures.

Attributes

Attribute NameValues
Title
  • Accelerated Progression Relapse Test

Patent Number
  • US 8597885 B2

USPTO Link
Inventor
  • Steven Buechler

Inventor From Local Institution
  • Steven Buechler

Other Application
  • 12/695,723

Prior Publication Date
  • 2010-08-05

Prior Publication Number
  • US 20100196906 A1

Claims
  • 5

Classification (US Patent)
  • 435/6.11; 435/4; 435/6.1;

Cooperative Patent Classification codes
  • C12Q 1/6886 (20130101); G01N 33/57415 (20130101); G06F 19/20 (20130101); C12Q 2600/106 (20130101); C12Q 2600/158 (20130101); G01N 2800/56 (20130101); G06F 19/24 (20130101)

International Patent Classification codes
  • C12Q 1/68 (20060101); C12Q 1/00 (20060101)

Language
  • eng

Date Issued
  • 2013-12-03

Publisher
  • United States Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

Record Visibility and Access Public
Content License
Departments and Units
Member of

Collections

Collections Featuring this Patent
Notre Dame Patents

Files

Please Note: You may encounter a delay before a download begins. Large or infrequently accessed files can take several minutes to retrieve from our archival storage system.