Mechanical Characterization and Simulation of Murine Thrombi

Master's Thesis

Abstract

Deep vein thrombosis, pulmonary embolism, and abdominal aortic aneurysms are blood-related diseases that represent a major public health problem. These diseases are characterized by the formation of a thrombus (i.e., blood clot) that either blocks a major artery or causes an aortic rupture. Identifying the mechanical properties of thrombi can help determine when these incidents will occur. In this investigation, a murine thrombus, formed from platelet-rich plasma, calcium, and thrombin, was nanoindented and the elastic modulus was determined via elastic contact theory. This information was used as input to an inverse finite element simulation, which synthesized optimal values for the elastic modulus and viscosity of the thrombus using a viscoelastic material model. A sensitivity analysis was also performed to determine which material parameters have the greatest affect on the simulation. Results from this investigation demonstrate the feasibility of the mechanical characterization of a murine thrombus using nanoindentation.

Attributes

Attribute NameValues
URN
  • etd-04152011-152830

Author Constance Lynne Slaboch
Advisor Dr. Timothy C. Ovaert
Contributor Dr. Timothy C. Ovaert, Committee Chair
Contributor Dr. Glen L. Niebur, Committee Member
Contributor Dr. Ryan K. Roeder, Committee Member
Degree Level Master's Thesis
Degree Discipline Aerospace and Mechanical Engineering
Degree Name MSME
Defense Date
  • 2011-04-05

Submission Date 2011-04-15
Country
  • United States of America

Subject
  • viscoelasticity

  • murine model

  • nanoindentation

  • venous thromboembolism

  • soft tissue characterization

  • thrombi mechanics

Publisher
  • University of Notre Dame

Language
  • English

Record Visibility and Access Public
Content License
  • All rights reserved

Departments and Units

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