Method for preparing largazole analogs and uses thereof

Patent

Description

Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

Attributes

Attribute NameValues
Title
  • Method for preparing largazole analogs and uses thereof

Patent Number
  • US 8513290 B2

USPTO Link
Inventor
  • Robert M. Williams

  • James E. Bradner

  • Albert Bowers

  • Tenaya Newkirk

  • Olaf G. Wiest

Inventor From Local Institution
  • Olaf Wiest

Other Application
  • 13/490,693

Prior Publication Date
  • 2012-10-18

Prior Publication Number
  • US 20120264794 A1

Claims
  • 9

Classification (US Patent)
  • 514/366; 514/374; 514/375; 514/471; 548/122; 548/125; 548/126; 548/215; 548/217; 548/220;

Cooperative Patent Classification codes
  • C07D 498/18 (20130101); A61K 39/39558 (20130101); A61K 31/429 (20130101); C07D 513/18 (20130101)

International Patent Classification codes
  • A61K 31/429 (20060101); A61K 31/424 (20060101); C07D 513/22 (20060101); C07D 513/18 (20060101); C07D 498/18 (20060101)

Language
  • eng

Date Issued
  • 2013-08-20

Publisher
  • United States Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

  • Colorado State University Research Foundation (Fort Collins, CO)

  • Dana-Farber Cancer Institute, Inc. (Boston, MA)

Record Visibility Public
Content License
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