Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics

Master's Thesis
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Abstract

The research in this thesis involved two main projects that focus on the development of novel antibiotics to overcome bacterial resistance problem. The first project involved the syntheses and biological evaluation of cephalosporin and oxazolidinone-based antibiotics using nitroso DielsÌ¢�âÂ"Alder and related chemistry. The second main project involved the syntheses and biological studies of cephalosporin-oxazolidinone dual action prodrugs. In Chapter 1, the synthesis of cephalosporin-based antibiotics using nitroso DielsÌ¢�âÂ"Alder chemistry was rationalized and described. Chapter 2 described the synthesis of novel oxazine and aminocycloalkenol containing oxazolidinone antibiotics using nitroso DielsÌ¢�âÂ"Alder chemistry. In addition, in vitro antibacterial studies were included. In chapter 3, cephalosporin-oxazolidinone multifunctional compounds were rationally designed and synthesized. Their stability in aqueous media in the presence of Beta-lactamase and in vitro antimicrobial activity were investigated

Attributes

Attribute NameValues
URN
  • etd-12092009-191500

Author Shanshan Yan
Advisor Professor Xavier Creary
Contributor Professor Xavier Creary , Committee Member
Contributor Professor Bradley D. Smith, Committee Member
Contributor Professor Richard E. Taylor, Committee Member
Contributor Professor Marvin J. Miller, Committee Member
Degree Level Master's Thesis
Degree Discipline Chemistry and Biochemistry
Degree Name MS
Defense Date
  • 2009-12-04

Submission Date 2009-12-09
Country
  • United States of America

Subject
  • Cephalosporin

  • Oxazolidinone

  • Conjugate

Publisher
  • University of Notre Dame

Language
  • English

Record Visibility and Access Public
Content License
  • All rights reserved

Departments and Units

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