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Probes for anionic cell surface detection

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posted on 2016-06-07, 00:00 authored by Bradley D SmithBradley D Smith
Embodiments of the present invention are generally directed to compositions comprising a class of molecular probes for detecting the presence of anionic cell surfaces. Embodiments include compositions that are enriched for these compositions and preparations, particularly preparations suitable for use as laboratory/clinical reagents and diagnostic indicators, either alone or as part of a kit. An embodiment of the invention provides for a highly selective agent useful in the discernment and identification of dead or dying cells, such as apoptotic cells, in a relatively calcium-free environment. An embodiment of the invention provides a selective agent for the identification of bacteria in a mixed population of bacterial cells and nonbacterial cells.

History

Patent Number

US 8389223 B2

Other Application

12/874,689

Inventor

Bradley D. Smith

Inventor from Local Institution

Bradley D. Smith

Assignee

University of Notre Dame Du Lac

Date Modified

2016-06-07

Language

  • English

Claims

2

Prior Publication Number

US 20100331542 A1

Publisher

United States Patent and Trademark Office

Cooperative Patent Classification Codes

C12Q 1/04 (20130101); G01N 33/92 (20130101); G01N 2510/00 (20130101)

Contributor

Bradley D. Smith

International Patent Classification Codes

G01N 33/53 (20060101); C07F 15/04 (20060101)

US Patent Classification Codes

435/7.1; 435/7.21; 435/7.23; 546/12;

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