McNerneyMW042012D.pdf (36.85 MB)
No Stressing About Memory: An Investigation of Allopregnanolone and Nitric Oxide Effects on Long-Term Potentiation
thesis
posted on 2012-04-08, 00:00 authored by M. Windy McNerneyThe mechanisms of long-term potentiation were investigated in two sets of experiments. The first determined the effects of the neurosteroid allopregnanolone on long-term potentiation. Results revealed that allopregnanolone inhibits long-term potentiation primarily through its actions on the GABAA receptor. The second experiment used fluorescence microscopy to create a temporal analysis of nitric oxide synthesis in response to high-frequency stimulation and found that the concentration of nitric oxide increased at two separate time periods following the induction of long-term potentiation. These findings explain how it is possible for nitric oxide to be important for increased glutamate release during the initiation of long-term potentiation, as well as gene transcription during later stages. Future research should utilize the methods created in this study to further increase the knowledge of long-term potentiation, as well as determine the mechanisms behind abnormal nitric oxide levels found in various neurological diseases.
History
Date Modified
2017-06-05Defense Date
2012-04-04Research Director(s)
Gabriel RadvanskyDegree
- Doctor of Philosophy
Degree Level
- Doctoral Dissertation
Language
- English
Program Name
- Psychology
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