US8257715.pdf (2.95 MB)
Tissue vaccines and uses thereof
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posted on 2016-06-07, 00:00 authored by Mark A. Suckow, Morris Pollard, William R. WolterCompositions comprising a tissue vaccine that include a mixture of heterogeneous tissue obtained from tumors and connective tissues. Vaccines comprising these compositions are also provided, as well as methods of using the vaccines in the treatment and/or inhibition of tumor growth, and particularly prostate tumor growth and cancers. The preparations may be defined as vaccines comprising tumor cells and connective (stromal) tissues derived from xenogeneic animals. Preparations comprising the tissue vaccines are provided using tissue harvested directly from tumors. Methods for preventing de novo development of cancer are also disclosed. A tissue vaccine comprising glutaraldehyde-(GFT) treated tissue prepared from tumor and connective tissue reduces the incidence of autochthonous prostate cancer. A tissue vaccine comprising a potassium thiocyanate extract (PTE) preparation of a tumor and connective tissue is also provided. The tissue vaccines are demonstrated to reduce the incidence of autochthonous prostate cancer.
History
Patent Number
US 8257715 B2Other Application
11/209,766Inventor
Mark A. Suckow William R. Wolter Morris PollardInventor from Local Institution
Mark A. Suckow William R. Wolter Morris PollardAssignee
University of Notre Dame Du LacDate Modified
2016-06-07Language
- English
Claims
41Publisher
United States Patent and Trademark OfficeCooperative Patent Classification Codes
A61K 39/0011 (20130101); A61K 2039/5152 (20130101)Contributor
Mark A. Suckow|William R. Wolter|Morris PollardInternational Patent Classification Codes
A61K 39/00 (20060101)US Patent Classification Codes
424/277.1Usage metrics
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