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A Picometer-Diameter Pore in an Inorganic Membrane for Sequencing Protein

journal contribution
posted on 2019-08-07, 00:00 authored by Clare Tennant, Eamonn Kennedy, Gregory Timp, Zhuzin Dong
Disclosed are then inorganic membranes having a defined topography that includes pores having a defined diameter of nanometer and sub-nanometer diameter. The thin membranes are resistant to protein denaturing agents, and may be employed in analytical and clinical methods for identifying single amino acid residues within the sequence of a protein and the pores are other than NspA pores. Methods for making a thin inorganic membrane with nanopore and sub-nanopore topography and conical cone structure are also disclosed. The thin inorganic membrane may be comprised of any denaturant-resistant materials, such as silicon nitride. A method for manufaacturing the thin inorganic membrane with nanopores is also provided, and provides a thin surface with a defined conical topography, the nanopores being provided on the membrane surface with an electron beam sputinger technique.

History

Alt Title

United States Patent Application Publication

Date Modified

2019-08-07

Language

  • English

Publisher

US Patent Office

Contributor

University of Notre Dame

Source

US20190064110A1

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