Disclosed are then inorganic membranes having a defined topography that includes pores having a defined diameter of nanometer and sub-nanometer diameter. The thin membranes are resistant to protein denaturing agents, and may be employed in analytical and clinical methods for identifying single amino acid residues within the sequence of a protein and the pores are other than NspA pores. Methods for making a thin inorganic membrane with nanopore and sub-nanopore topography and conical cone structure are also disclosed. The thin inorganic membrane may be comprised of any denaturant-resistant materials, such as silicon nitride. A method for manufaacturing the thin inorganic membrane with nanopores is also provided, and provides a thin surface with a defined conical topography, the nanopores being provided on the membrane surface with an electron beam sputinger technique.
A Picometer-Diameter Pore in an Inorganic Membrane for Sequencing Protein
DocumentAbstract
Attribute Name | Values |
---|---|
Document Type |
|
Alternate Title |
|
Creator |
|
Date Created |
|
Publisher |
|
Subject |
|
Source |
|
Language |
|
Repository Name |
|
Contributor Institution |
|
Record Visibility and Access | Public |
Content License |
|
Departments and Units |