Gelatinase inhibitors and prodrugs

Patent

Description

The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be selective inhibition, for example, selective inhibition of MMP-2, MMP-9, and/or MMP-14. Thus, the invention provides non-mutagenic prodrug compounds of the formulas described herein that result in the inhibition of MMPs upon in vivo administration.

Attributes

Attribute NameValues
Title
  • Gelatinase inhibitors and prodrugs

Patent Number
  • US 9867805 B2

USPTO Link
Inventor
  • Mayland Chang

  • Shahriar Mobashery

  • Mijoon Lee

Inventor From Local Institution
  • Mayland Chang

  • Shahriar Mobashery

  • Mijoon Lee

Other Application
  • 15/139,055

Prior Publication Date
  • 2016-12-01

Prior Publication Number
  • US 20160346247 A1

Claims
  • 17

Cooperative Patent Classification codes
  • C07D 331/02 (20130101); C07D 409/12 (20130101); A61K 38/49 (20130101); A61K 38/4886 (20130101); A61K 38/482 (20130101); A61K 31/38 (20130101); C12Y 304/24017 (20130101); C12Y 304/24007 (20130101); C12Y 304/21073 (20130101); C12Y 304/21068 (20130101); C12Y 304/24035 (20130101); C12Y 304/24023 (20130101); C12Y 304/21 (20130101)

International Patent Classification codes
  • A61K 38/00 (20060101); C07K 16/00 (20060101); A61K 38/49 (20060101); A61K 38/48 (20060101); C07D 409/12 (20060101); C07D 331/02 (20060101); A61K 31/38 (20060101); C07K 17/00 (20060101); C07K 14/00 (20060101); C07K 7/00 (20060101); C07K 5/00 (20060101); C07K 4/00 (20060101); C07K 2/00 (20060101)

Language
  • English

Date Issued
  • 2018-01-16

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

Record Visibility and Access Public
Content License
  • All rights reserved

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