9872870OCR.pdf (1.53 MB)
Multifunctional micellar nanoparticle-based drug and targeting agent system
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posted on 2018-08-06, 00:00 authored by Jared F. Stefanick, Jonathan D. Ashley, Michael W. Handlogten, Nathan J. Alves, Tanyel Kiziltepe Biligicer, Z. Basar BilgicerEmbodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cell. The therapeutic component may be subsequently released within an endocytic vesicle of the target cell. Nanoparticle-based drug delivery systems as described herein may provide improved efficacy and/or reduced toxicity.
History
Patent Number
US 9872870 B2Other Application
14/356,121Inventor
Z. Basar Bilgicer Tanyel Kiziltepe Bilgicer Jonathan D. Ashley Jared F. Stefanick Nathan J. Alves Michael W. HandlogtenInventor from Local Institution
Z. Basar Bilgicer Tanyel Kiziltepe Bilgicer Jonathan D. Ashley Jared F. Stefanick Nathan J. Alves Michael W. HandlogtenAssignee
University of Notre Dame Du LacDate Modified
2022-01-16Language
- English
Claims
18Prior Publication Number
US 20140287049 A1Publisher
U.S. Patent and Trademark OfficeCooperative Patent Classification Codes
A61K 31/351 (20130101); A61K 51/0455 (20130101); A61K 31/704 (20130101); A61K 47/6907 (20170801); A61K 47/6909 (20170801); A61K 47/62 (20170801); A61K 9/1075 (20130101)Contributor
Z. Basar Bilgicer|Tanyel Kiziltepe Bilgicer|Jonathan D. Ashley|Jared F. Stefanick|Nathan J. Alves|Michael W. HandlogtenInternational Patent Classification Codes
A61K 9/133 (20060101); A61K 38/08 (20060101); A61K 31/704 (20060101); A61K 51/04 (20060101); A61K 31/351 (20060101); A61K 47/62 (20170101); A61K 47/69 (20170101); A61K 9/107 (20060101)Additional Groups
- Chemical and Biomolecular Engineering
- Chemistry and Biochemistry
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