Multifunctional micellar nanoparticle-based drug and targeting agent system

Patent

Description

Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cell. The therapeutic component may be subsequently released within an endocytic vesicle of the target cell. Nanoparticle-based drug delivery systems as described herein may provide improved efficacy and/or reduced toxicity.

Attributes

Attribute NameValues
Title
  • Multifunctional micellar nanoparticle-based drug and targeting agent system

Patent Number
  • US 9872870 B2

USPTO Link
Inventor
  • Z. Basar Bilgicer

  • Tanyel Kiziltepe Bilgicer

  • Jonathan D. Ashley

  • Jared Stefanick

  • Nathan J. Alves

  • Michael W. Handlogten

Inventor From Local Institution
  • Z. Basar Bilgicer

  • Tanyel Kiziltepe Bilgicer

  • Jonathan D. Ashley

  • Jared Stefanick

  • Nathan J. Alves

  • Michael W. Handlogten

Other Application
  • 14/356,121

Prior Publication Date
  • 2014-09-25

Prior Publication Number
  • US 20140287049 A1

Claims
  • 18

Cooperative Patent Classification codes
  • A61K 31/351 (20130101); A61K 51/0455 (20130101); A61K 31/704 (20130101); A61K 47/6907 (20170801); A61K 47/6909 (20170801); A61K 47/62 (20170801); A61K 9/1075 (20130101)

International Patent Classification codes
  • A61K 9/133 (20060101); A61K 38/08 (20060101); A61K 31/704 (20060101); A61K 51/04 (20060101); A61K 31/351 (20060101); A61K 47/62 (20170101); A61K 47/69 (20170101); A61K 9/107 (20060101)

Language
  • English

Date Issued
  • 2018-01-23

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

Record Visibility Public
Content License
  • All rights reserved

Departments and Units
Member of

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