Tissue vaccines and uses thereof

Patent

Description

Compositions comprising a tissue vaccine that include a mixture of heterogeneous tissue obtained from tumors and connective tissues. Vaccines comprising these compositions are also provided, as well as methods of using the vaccines in the treatment and/or inhibition of tumor growth, and particularly prostate tumor growth and cancers. The preparations may be defined as vaccines comprising tumor cells and connective (stromal) tissues derived from xenogeneic animals. Preparations comprising the tissue vaccines are provided using tissue harvested directly from tumors. Methods for preventing de novo development of cancer are also disclosed. A tissue vaccine comprising glutaraldehyde-(GFT) treated tissue prepared from tumor and connective tissue reduces the incidence of autochthonous prostate cancer. A tissue vaccine comprising a potassium thiocyanate extract (PTE) preparation of a tumor and connective tissue is also provided. The tissue vaccines are demonstrated to reduce the incidence of autochthonous prostate cancer.

Attributes

Attribute NameValues
Title
  • Tissue vaccines and uses thereof

Patent Number
  • US 8062646 B2

USPTO Link
Inventor
  • Mark A. Suckow

  • William R. Wolter

  • Morris Pollard

Inventor From Local Institution
  • Mark A. Suckow

  • William R. Wolter

  • Morris Pollard

Other Application
  • 11/924,459

Prior Publication Date
  • 2008-07-03

Prior Publication Number
  • US 20080160049 A1

Claims
  • 12

Classification (US Patent)
  • 424/277.1;

Cooperative Patent Classification codes
  • A61K 39/0011 (20130101); A61K 2039/5152 (20130101)

International Patent Classification codes
  • A61K 39/00 (20060101)

Language
  • eng

Date Issued
  • 2011-11-22

Publisher
  • United States Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

Record Visibility and Access Public
Content License
Departments and Units
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Collections Featuring this Patent
Notre Dame Patents

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