9975121OCR.pdf (1.21 MB)
Microfluidic devices, systems, and methods for evaluating tissue samples
standard
posted on 2018-08-07, 00:00 authored by Cody Narciso, David Hoelzle, Jeremiah Zartman, Siyuan ZhangA microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon application of pressure thereto, to mechanically compress the tissue sample; (2) first and second electrodes disposed about the tissue chamber and being configured such that delivery of electrical energy thereto creates an electrical gradient across the tissue chamber; and (3) at least one deformable wall, which partially defines the tissue chamber and is configured to stretch either uniaxially or biaxially upon application of negative pressure to the tissue chamber.
History
Patent Number
US 9975121 B2Other Application
14/738,335Inventor
Siyuan Zhang Jeremiah Zartman David Hoelzle Cody NarcisoInventor from Local Institution
Siyuan Zhang Jeremiah Zartman David Hoelzle Cody NarcisoAssignee
University of Notre Dame Du LacDate Modified
2018-08-07Language
- English
Claims
10Prior Publication Number
US 20150360224 A1Publisher
U.S. Patent and Trademark OfficeCooperative Patent Classification Codes
B01L 3/502715 (20130101); C12M 23/16 (20130101); B01L 2300/0645 (20130101); B01L 2300/123 (20130101); B01L 2300/06 (20130101); B01L 2400/0439 (20130101); B01L 2200/028 (20130101); B01L 2200/025 (20130101); B01L 2200/0647 (20130101); B01L 2200/143 (20130101); B01L 2300/023 (20130101); B01L 2300/044 (20130101); B01L 2400/0481 (20130101); B01L 2400/0487 (20130101)Contributor
Siyuan Zhang|Jeremiah Zartman|David Hoelzle|Cody NarcisoInternational Patent Classification Codes
B01L 3/00 (20060101); C12M 3/06 (20060101)Additional Groups
- Aerospace and Mechanical Engineering
- Chemical and Biomolecular Engineering
- Biological Sciences
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