Microfluidic devices, systems, and methods for evaluating tissue samples

Patent

Description

A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon application of pressure thereto, to mechanically compress the tissue sample; (2) first and second electrodes disposed about the tissue chamber and being configured such that delivery of electrical energy thereto creates an electrical gradient across the tissue chamber; and (3) at least one deformable wall, which partially defines the tissue chamber and is configured to stretch either uniaxially or biaxially upon application of negative pressure to the tissue chamber.

Attributes

Attribute NameValues
Title
  • Microfluidic devices, systems, and methods for evaluating tissue samples

Patent Number
  • US 9975121 B2

USPTO Link
Inventor
  • Siyuan Zhang

  • Jeremiah Zartman

  • David Hoelzle

  • Cody Narciso

Inventor From Local Institution
  • Siyuan Zhang

  • Jeremiah Zartman

  • David Hoelzle

  • Cody Narciso

Other Application
  • 14/738,335

Prior Publication Date
  • 2015-12-17

Prior Publication Number
  • US 20150360224 A1

Claims
  • 10

Cooperative Patent Classification codes
  • B01L 3/502715 (20130101); C12M 23/16 (20130101); B01L 2300/0645 (20130101); B01L 2300/123 (20130101); B01L 2300/06 (20130101); B01L 2400/0439 (20130101); B01L 2200/028 (20130101); B01L 2200/025 (20130101); B01L 2200/0647 (20130101); B01L 2200/143 (20130101); B01L 2300/023 (20130101); B01L 2300/044 (20130101); B01L 2400/0481 (20130101); B01L 2400/0487 (20130101)

International Patent Classification codes
  • B01L 3/00 (20060101); C12M 3/06 (20060101)

Language
  • English

Date Issued
  • 2018-05-22

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

Record Visibility and Access Public
Content License
  • All rights reserved

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